In this issue: 1. Kigali Amendment latest ratifications. 2. Summary of the Combined Twelfth Meeting of the Conference of the Parties to the Vienna Convention for the Protection of the Ozone Layer (part II) and the Thirty-Third Meeting of the Parties to the Montreal Protocol on Substances that Deplete the Ozone Layer: 23-29 October 2021. 3. Vienna Convention, Montreal Protocol Offer Lessons for Climate Agreements. 4. 2021 Antarctic Ozone Hole 13th Largest Since 1979. 5. Status of the Global Food Cold-Chain. 6. OzonAction and IIR Shine the Spotlight on Vaccine Cold Chain Technology. 7. World Bank Mobilizes USD$157 million for Clean Cooling from Green Climate Fund. 8. WMO supports new Sun-Smart UV App. 9. Rwanda Environment Management Authority (REMA) urges switch to climate-friendly fridges. 10. Asia-Pacific launch a year-long Ozone2Climate Art Contest. 11. HFC phase-down: India can solve its cooling problem through collaborative research, development and deployment. 12. 4 innovative technologies that can replace ACs and refrigeration. 13. Are you ready to take action on climate friendly refrigerants? 14. US EPA considers R410A ban from 2025. 15. Protecting the ozone layer could prevent cancer cases and other diseases in the U.S. 16. New EU funded project began on October 1st, 2021: “SophiA - Sustainable off-grid solutions for pharmacies and hospitals in Africa”. 17. El papel de los refrigerantes naturales en la climatización y refrigeración.